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While this may not be a perfectly executed study, the "N=1 trial" part is not the problem.

There have been numerous medical and scientific studies with N=1, known as N-of-1 trials. These trials are very useful in chronic conditions where symptoms are stable and measurable, allowing for multiple crossover periods to assess treatment effects accurately.

Also…don't forget all the medical discoveries based on self-experimentation:

Werner Forssmann performed the first heart catheterization on himself. He got the Nobel prize.

Barry Marshal injected himself with heliobacter pylori to prove that it causes stomach ulcers. Also got the Nobel prize.

Jessie Lazear allowed himself to be bitten by mosquitoes infected with yellow fever to prove his hypothesis that mosquitoes were the vector for transmission. No Nobel prize, but he did contract the disease, thus proving his hypothesis…before dying from yellow fever two weeks later.


>Werner Forssmann performed the first heart catheterization on himself. He got the Nobel prize.

In case anyone else was confused how it would be possible to perform heart surgery on yourself, he did it through a vein in his arm, which is still incredibly impressive:

>In 1929, he put himself under local anesthesia and inserted a catheter into a vein of his arm. Not knowing if the catheter might pierce a vein, he put his life at risk. Forssmann was nevertheless successful; he safely passed the catheter into his heart.

He also had to trick the operating-room nurse into thinking he was operating on her.


Through the arm, I believe, is still the way it’s performed today!


Nobel candidates cannot be deceased.


Unless you are Kai Krause and very determined to make some users love your GUI while the rest scream in agony.


> Headphones had to cross that barrier

Even mobile phones! I'm old enough to remember the first "popular" models in the 80's, like the Ericsson Hotline. Sure, the phone might've been cool, but the people using them certainly were not.

Regarding the headset, I have a feeling that the hardware simply might still be far too immature. Imagine if we had the tech to put augmented reality and actually smart/helpful ai tools in the form factor of contact lenses, paired with a reasonable pricetag. I think that would be an instant hit.


Turning off Siri is the first thing I do on every new Apple device I get.

Too many "Siri, play my gym playlist" -> "Sure, calling your boss" at 9 pm on a Sunday.


Me too except for my watch, where it's very useful advancing/replaying a song while I'm out running in the cold with gloves on.


I'm still on iPhone 7+… It gets a new battery every 2-3 years and works great. I love how it has a big screen but feels much smaller and thinner in my pocket than any modern iPhone. I was really looking forward to this new "SE4", but the 7.5W charging and lack of magsafe is a deal breaker for a phone that in my country costs ~900 usd.


> The worst thing a corporation is likely to do (other than giving your data to governments) is to sell you something. That's all they want.

That's not all they want.

Just look at some recent scandals, like Cambridge Analytica. Harvesting and analyzing the right data makes it possible to influence democratic elections and referendums.

Selling you stuff is great, but tricking you to vote for lower taxes for their trillion-dollar corporations or tariffs/other negative effects for their competitors is better.


Valid question though, and the answer to what I think you wanted to know is >3 months:

> the clams are “paid back after three months of work by releasing them to a place from which they will never be caught again”. [---] this is done because they eventually become resistant to contamination in the water.

https://www.zmescience.com/ecology/poznan-mussel-water-plant...


Also, trojan rats:

> During WWII, British Special Forces considered stuffing dead rats with explosives and dispersing them over Germany. They hoped that the Germans would gather the rats and dispose of them in industrial furnaces, producing tremendous explosions that would cause catastrophic boiler failures.

https://www.theguardian.com/uk/1999/oct/27/richardnortontayl...


One of my pet peeves is when rules counteract the purpose they are supposed to serve, usually because of incompetence. Two years ago, I worked for a few months for a company where time reporting was accessed through a specific web page.

They required the password to be changed monthly, have at least 10 characters, at least one number and at least one special character. On top of that – they locked out password managers and pasting. "We need to make sure you are the one logging in and not a hacker that hacked your password manager" they explained when I asked.

Out of spite I went for "Password12!" the first month and "Password123!" the month after, at which point I received an email from the IT department explaining to me that my choice of password was endangering the corporations security.


> I received an email from the IT department explaining to me that my choice of password was endangering the corporations security.

Sounds like they were logging/storing passwords in plaintext.


Or offline cracking passwords using a wordlist.


Isn't it nice that hackers give up as soon as they realize they can't paste the password in?

And password managers (keepassxc anyways) have a pretty nifty auto-type feature that gets around that anyways.


Have you heard of the Cobra Effect?


> What projects in developed countries have used cut and cover recently?

Not really a new project, but parts of the subway in Stockholm are cut and cover. One of those tunnels (from the 1930s) has been leaking in water for some years and is up for a total overhaul, so basically digging up everyting and doing a new cover.

The section is 8 m wide and 925 m long, projected timeline is 6-7 years starting this fall. It will be a massive project, as one of the busiest streets in Stockholm is directly on top of it.


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