It seems like a vanishingly small chance that us-east-1 will have a total meltdown across its 6 AZ's.
But us-east-1 appears to be the most problematic region (instance launch issues, API issues, etc), so for that reason alone, I wouldn't build a new deployment there. If I wanted proximity to the east coast, I'd probably go with us-east-2 (Ohio) with a backup in ca-central-1.
I'm not worried about surviving a meteor strike or Carrington Event, not much point in keeping a company alive when its employees and customers are struggling to survive.
But us-east-1 appears to be the most problematic region (instance launch issues, API issues, etc), so for that reason alone, I wouldn't build a new deployment there. If I wanted proximity to the east coast, I'd probably go with us-east-2 (Ohio) with a backup in ca-central-1.
I'm not worried about surviving a meteor strike or Carrington Event, not much point in keeping a company alive when its employees and customers are struggling to survive.