Haha I tossed together that sentance before running to a meeting. I simply know the topic to such detail and intimately that I didn't think to make it simpler. If I had known it was going to be tossed at ChatGPT I would have fleshed it out more. The key thing that ChatGPT missed in its summary was that the entire PVN is often downregulated in Alzheimer's. This is where you get all of the other comorbidities that don't make sense and are red herrings such as thyroid issues and leads to a direct pathway to the reduction of myelin sheaths which is a crucial requirement before dementia.

Once you see the pathway you can't unsee it.