That's certainly true in the sense that flying from NYC to LA is 750x safer than doing the same as a road trip, on a fatalities-per-km basis. But on a per-trip basis, boarding that flight will be about equally as safe as taking a 5 km trip by car to the hardware store, and above-average defensive driving can certainly boost that radius considerably, maybe to 50 km.

Some would argue the per-trip comparison is invalid, but often the travel distance is not fixed, such as if you were weighing between vacation options of flying to NYC vs camping at a local campsite.

On a danger-per-hour-in-vehicle basis, airplanes of course still come out ahead, although not quite as overwhelmingly. NYC to LA is about a 5.5 hour flight; an equivalent drive would be about 350 km, and it will be very hard to match the safety of that flight even with defensive driving. You'd need to drive 70x better than average, even with the fatigue of a 5.5 hour drive.