I have a mini PC + 4x external HDDs (I always bought used) on Windows 10 with ReFS since probably 2016 (recently upgraded to Win 11), maybe earlier. I don't bother powering off.
The only time I had problems is when I tried to add a 5th disk using a USB hub, which caused drives attached to the hub get disconnected randomly under load. This actually happened with 3 different hubs, so I since stopped trying to expand that monstrosity and just replace drives with larger ones instead. Don't use hubs for storage, majority of them are shitty.
Currently ~64TiB (less with redundancy).
Same as OP. No data loss, no broken drives.
A couple of years ago I also added an off-site 46TiB system with similar software, but a regular ATX with 3 or 4 internal drives because the spiderweb of mini PC + dangling USBs + power supplies for HDDs is too annoying.
The only time I had problems is when I tried to add a 5th disk using a USB hub, which caused drives attached to the hub get disconnected randomly under load. This actually happened with 3 different hubs, so I since stopped trying to expand that monstrosity and just replace drives with larger ones instead. Don't use hubs for storage, majority of them are shitty.
Currently ~64TiB (less with redundancy).
Same as OP. No data loss, no broken drives.
A couple of years ago I also added an off-site 46TiB system with similar software, but a regular ATX with 3 or 4 internal drives because the spiderweb of mini PC + dangling USBs + power supplies for HDDs is too annoying.
I do weekly scrubs.
Some notes: https://lostmsu.github.io/ReFS/