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These types of arguments are somewhat worthless when they're not made in context to obesity.

What I mean is, you should be comparing the risk of GLP-1s versus the risk of obesity, because realistically this is the vast majority of people's risk analysis criteria here.

Obesity increases your risk of CVD, metabolic syndrome, diabetes, liver disease, kidney disease, joint diseases, and overall mortality. CVD, in particular, is the number 1 cause of death in many developed countries.

Like all drugs, GLP-1s come with risk. This fact, however, is worthless. We must ask if it is less risky than the aggregate sum of the above diseases. I think the answer is overwhelming yes.

Therefore, obese people should probably consider GLP-1 medications. Particularly if they have tried, and failed, weight loss before. Which every obese person has.

In addition, when considering the downside of medication, we MUST compare it to the alternatives. Many obese people are already on multiple life-long medications. Statins, hypertension medication, insulin and other diabetes management drugs, etc.

Not only do these medications require significantly more management than a GLP-1, but they, too, come with their own set of risks, which we must then add to the risk of disease.

I, personally, have taken multiple chemotherapy drugs to cure my cancer. These drugs make GLP-1s look like nothing. They have damaged my body in irreversible ways. They've aged my blood, exposed me to extreme levels of known carcinogens, raised my risk of mortality, and overall lowered my quality of life.

However, I am thankful for them. Yes, my risk of mortality is much higher. But, compared to cancer, which has a 100% chance to kill me, it was a worthy tradeoff.



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