I cashed out a significant amount a few years ago to help pay for an IVF attempt (sadly, it didn't work out for us, but no regrets). Obviously that amount would represent a large sum today.
On the flip side, when I was packing up our house, I found some old paper wallets that I assumed were empty (from a time when I was doing some experimentation with various scripts). One of them had about $2k in BTC, that I promptly added to our downpayment on our new house.
kinda similar story on my end except instead of finding new BTC I rode the doge pump into tripling my money in about 48 hours and put that down on a house (which was worth even more because I was able to get 2021 mortgage rates instead of having to save until the fed hiked them again)
On the flip side, when I was packing up our house, I found some old paper wallets that I assumed were empty (from a time when I was doing some experimentation with various scripts). One of them had about $2k in BTC, that I promptly added to our downpayment on our new house.